WWC's Lab

Hung CL, Cheng HH, Hsieh WC, Tsai ZTY, Tsai HK, Chu CH, Hsieh WP, Chen YF, Tsou Y, Lai CH*, and Wang WC* (2015). The CrdRS two-component system responds to nitrosative stress in Helicobacter pylori. Mol. Microbiol. doi:10.1111/mmi.13089.

Du SY, Wang HJ, Cheng HH, Chen SD, Wang LHC, and Wang WC* (2014). Cholesterol glucosylation by Helicobacter pylori delays internalization and arrests phagosome maturation in macrophages. J. Microbiol. Immunol. Infect. Accepted. DOI. 10.1016/j.jmii.2014.05.011.

Chu CH, Wang LY, Hsu KC, Chen CC, Cheng HH, Wang SM, Wu CM, Chen TJ, Li LT,Liu R, Hung CL, Yang JM*, Kung HJ* and Wang WC*. KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J. Med. Chem.2014(14), 57, 5975-5985. July 24.

Wang HJ, Hsieh YJ, Cheng WC, Lin CP, Lin YS, Yang SF, Chen CC, Izumiya Y, Yu JS, Kung HJ*, and Wang WC* (2014). JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1a-mediated glucose metabolism. Proc. Natl. Acad. Sci. USA 111, 279-284.

Lai CC, Yeh YH, Hsieh WP, Kuo CT, Wang WC, Chu CH, Hung CL, Cheng CY, Tsai HY, Lee JL, Tang  CY, Hsu LA (2013). Whole-exome sequencing to identify a novel LMNA gene mutation associated with inherited cardiac conduction disease. PLoS ONE8, e83322.

Lai CH*, Hsu YM, Wang HJ, Wang WC* (2013) Manipulation of host cholesterol byHelicobacter pylori for their beneficial ecological niche. BioMedicine 3, 27-33.

Lin ST, Lo YW, Chang SJ, Wang WC, Chang MD, Lyu PC, Chen WY, Chou HC, and Chan HL*. (2013) Redox-proteomic analysis of doxorubicin resistance-induced altered thiol activity in uterine carcinoma. J. Pharm. Biomed. Anal. 78-79C, 1-8.

Hsu KC, Cheng WC, Chen YF, Wang WC* and Yang JM* (2013). Pathway-based screening strategy for multitarget inhibitors. PLoS Comput. Biol. 9, e1003127.

Chang PC, Cheng CY, Campbell M, Yang YC, Hsu HW, Chang TY, Chu CH, Lee YW, Hung CL, Lai SM, Tepper CG, Hsieh WP, Wang HW, Tang CY, Wang WC, Kung HJ (2013). The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi’s sarcoma associated herpesvirus reactivation. BMC Genomics. 14, 824.    

Wang HJ, Cheng WC, Cheng HH, Lai CH, and Wang WC* (2012). Helicobacter pyloricholesteryl glucosides interfere host membrane phase and affect type IV secretion system Function during Infection in AGS Cells. Mol. Microbiol. 83, 67-84.

Wu HM, Kuan YC, Chu CH, Hsu WH, and Wang WC* (2012). The crystal structures of Lysine-preferred racemases, a target to develop non-antibiotic selectable markers for transgenic plants. PLoS ONE, 7, e48301.   

Hsu KC, Cheng WC, Chen YF, Lin SC, Chen TJ, Wang WC*, Yang JM* (2012). Core site-moiety maps reveal inhibitors and binding mechanisms of orthologous proteins by screening compound libraries. PLoS ONE 7, e32142.

Cheng HH, Tseng GY, Yang HB, Wang HJ, Lin HJ, Wang WC* (2012). Increased numbers of Foxp3-positive regulatory T cells in gastritis, peptic ulcer, and gastric adenocarcinoma. World J. Gastroenterol. 18, 34–43.

Cheng WC, Chen YF, Wang HJ, Hsu KC, Lin SC, Chen TJ, Yang JM*, Wang WC* (2012). Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor–induced-fit mechanism, PLoS ONE 7, e33481.

Lai CH, Wang, HJ, Chang YC, Hsieh WC, Lin HJ, Tang CH, Sheu J JC, Lin CJ. Yang MS, Tseng SF, Wang WC* (2011). Helicobacter pylori CagA-mediated IL-8 induction in gastric epithelial cells is cholesterol-dependent and requires the C-terminal tyrosine phosphorylation-containing domain FEMS Microbiology Let. 323, 155–163.

Cheng HH, Chang CS, Wang HJ, and Wang WC* (2010). IL-1 and IL-10 polymorphisms influence erosive reflux esophagitis and gastritis in Taiwanese patients. J. Gastroenterol. Hepatol. 25, 1443–1451.

Chen YF, Hsu KC, Lin SR, Wang WC, Huang YC, Yang JM (2010). SiMMap: a web server for inferring site-moiety map to recognize interaction preferences between protein pockets and compound moieties. Nucleic Acids Res. 38 Suppl, W424-430.

Kan SC, Hu HY, Liu JS, Chang CM, Lin WD, Wang WC*, and Hsu WH*. Biochemical characterization of two thymidylate synthases in Corynebacterium glutamicum NCHU 87078 (2010). BBA-Proteins and Proteomics 1804, 1751-1759.

Poon SK, Lai CH, Chang CS, Lin WY, Chang YC, Wang HJ, Lin PH, Lin HJ, and Wang WC* (2009). Prevalence of antimicrobial resistance of Helicobacter pylori isolates in Taiwan in relation to the consumption of antimicrobial agents. Inter. J. Antimicrob. Agents 34, 162–165.

Wu HM, Liu SW, Hsu MT, Hung CL, Lai CC, Cheng WC, Wang HJ, Li YK, and Wang WC* (2009). Structure, mechanistic action, and essential residues of a GH-64 enzyme--laminaripentaose-producing b-1,3-glucanase. J. Biol. Chem. 284, 26708–26715.

Liu JS, Cheng WC, Wang HJ, Chen YC, Wang WC* (2008). Structure-based inhibitor discovery of Helicobacter pylori dehydroquinate synthase. Biochem. Biophys. Res. Commun. 373, 1–7.

Lai CH, Chang YC, Du SY, Wang HJ, Kuo CH, Fang SH, Fu HW, Lin HH, Chiang AS, and Wang WC* (2008). Cholesterol depletion reduces Helicobacter pylori CagA translocation and CagA-induced responses in AGS cells. Infect. Immun. 76,3293–3303.

Hung CL, Liu JH, Chiu WC, Huang SW, Hwang JK, and Wang WC*. Crystal structure ofHelicobacter pylori formamidase AmiF reveals a cysteine-glutamate-lysine catalytic triad (2007). J. Biol. Chem. 282, 12220–12229.

Lee YC, Wu HM, Chang YN, Wang WC*, and Hsu WH (2007). The central cavity from the (alpha/alpha)6 barrel structure of Anabaena sp. CH1 N-acetyl-D-glucosamine 2-epimerase contains two key histidines for reversible conversion. J. Mol. Biol. 367, 895–908. SCI.

Chiu WC, You JY, Liu JS, Hsu SK, Hsu WH, Shih CH, Hwang JK, Wang WC* Structure-stability-activity relationship in covalently cross-linked N-carbamoyl D-amino acid amidohydrolase and N-acylamino acid racemase (2006). J. Mol. Biol. 359, 741–753.SCI.

Lai CH, Kuo CH, Chen PY, Poon SK, Chang CS and Wang WC* (2006). Association of antibiotic resistance and higher internalization activity in resistant Helicobacter pyloriisolates. J. Antimicrob. Chemother. 57, 466–471.